Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-1-methylbenzimidazole → N-(1-(2-((1-methyl-1H-benzo[d]imidazol-2-yl)amino)ethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-1-methylbenzimidazole | HCID 74187 | — |
| 반응물 | N-(1-(2-oxoethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide | HCID 86704232 | — |
| 촉매 | Acetic Acid | HCID 176 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N-(1-(2-((1-methyl-1H-benzo[d]imidazol-2-yl)amino)ethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide | HCID 86704234 | — |
반응 단계
To a solution of N-(1-(2-oxoethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide (157 mg, 0.45 mmol) in MeCN (1 mL) and DCM (0.8 mL) was added 1-methyl-1H-benzo[d]imidazol-2-amine (66 mg, 0.45 mmol) followed by STAB (190 mg, 0.90 mmol) and 1 drop of AcOH. After stirring at rt for 18 h, the reaction mixture was filtered and directly purified by prep. HPLC. LC-MS conditions D: tR=0.77 min, [M+H]+=442.3.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09303023B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-9130f2bea5f74ed7b99ecb02a1f04190 |
| 출처 메모 | uspto-grants-2016_04 |