23138-53-6 → HCID 68748359, 화합물

HRID 624107노트

반응식

HRID 624107 반응식
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][NH:2]1.[N:10]([C:13]1[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=1)=[C:11]=[O:12]>O1CCCC1>[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][N:2]1[C:11]([NH:10][C:13]1[CH:22]=[CH:21][C:16]([C:17]([O:19][CH3:20])=[O:18])=[CH:15][CH:14]=1)=[O:12]

참가 물질

4

반응물 2

HCID 28045423138-53-6HCID 422478Isoindoline

생성물 1

HCID 68748359HCID 68748359, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
0 °C

실험 절차

Isoindoline (1.693 ml, 14.47 mmol) was dissolved in tetrahydrofuran (20 ml) and cooled to 0° C.; and methyl 4-isocyanatobenzoate (2.18 g, 12.06 mmol) was added by syringe and the resulting mixture was warmed to ambient temperature, and then stirred overnight. The solution was concentrated to a slurry, diluted with ether, and filtered to provide the title compound.

후처리

  1. temperaturethe resulting mixture was warmed to ambient temperature
  2. concentrationThe solution was concentrated to a slurry
  3. additiondiluted with ether
  4. filtrationfiltered

출처 및 근거

ORD 기록
ord-8c9f8c65e6764971b49cc7a235da57bc
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09302989B2

반응 노트

불러오는 중…