Water → HCID 68754457, 화합물

HRID 624154노트

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HRID 624154 반응식
[N:1]([C:4]1[CH:9]=[CH:8][C:7]([B:10]([OH:12])[OH:11])=[CH:6][CH:5]=1)=[C:2]=[O:3].[CH2:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][NH:14]1.O>ClCCl>[CH3:15][C:16]1([CH3:17])[C:21]([CH3:13])([CH3:20])[O:12][B:10]([C:7]2[CH:6]=[CH:5][C:4]([NH:1][C:2]([N:14]3[CH2:15][C:16]4[C:21](=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH2:13]3)=[O:3])=[CH:9][CH:8]=2)[O:11]1

참가 물질

5

반응물 3

HCID 962WaterHCID 422478IsoindolineHCID 57416338(4-Isocyanatophenyl)boronic acid

생성물 1

HCID 68754457HCID 68754457, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

500 mg (4-Isocyanatophenyl)boronic acid pinacolester (1.979 mmol) and 365 mg isoindoline (2.97 mmol) were dissolved in 10 ml dichloromethane and the resultant mixture was stirred over night at room temperature. After adding water, the mixture was extracted several times with dichloromethane, the combined organic phases were washed with dried over magnesium sulfate and filtered. The solvent was evaporated under reduced pressure. Column chromatography of the residue with dichloromethane resulted in the title compound.

후처리

  1. extractionthe mixture was extracted several times with dichloromethane
  2. washthe combined organic phases were washed
  3. dry with materialwith dried over magnesium sulfate
  4. filtrationfiltered
  5. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-7530678d204e42f88e0f0a936c3c32da
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09302989B2

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