3-Hydroxybenzaldehyde → 3-(Dimethylaminomethyl)phenol

HRID 624328

반응식

HRID 624328 반응식
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[CH3:10][NH:11][CH3:12].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].CO>C1COCC1.C(Cl)Cl>[CH3:10][N:11]([CH2:5][C:4]1[CH:3]=[C:2]([OH:1])[CH:9]=[CH:8][CH:7]=1)[CH3:12]

참가 물질

7

반응물 4

HCID 1013-HydroxybenzaldehydeHCID 674DimethylamineHCID 887MethanolHCID 5049666Sodium triacetoxyborohydride

생성물 1

HCID 328963-(Dimethylaminomethyl)phenol

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8028Tetrahydrofuran용매

실험 절차

3-Hydroxybenzaldehyde (1.0 g), 2M dimethylamine in THF (5 mL), and sodium triacetoxyborohydride (2 g) in CH2Cl2 (10 mL) were stirred for 24 hours. The mixture was treated with methanol and chromatographed on silica gel with 2-25% ethyl acetate/hexanes.

후처리

  1. customchromatographed on silica gel with 2-25% ethyl acetate/hexanes

출처 및 근거

ORD 기록
ord-fb8d2162ac9c4c14a6d8c52ea581c100
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303025B2

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