Triethylamine → 1-Fluoro-2-[(trifluoromethyl)sulfanyl]benzene

HRID 624364노트

반응식

HRID 624364 반응식
[F:1][C:2](I)([F:4])[F:3].[F:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[SH:13].C(N(CC)CC)C>CN(C)C=O.O>[F:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[S:13][C:2]([F:4])([F:3])[F:1]

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 16843TrifluoroiodomethaneHCID 5202162-Fluorothiophenol

생성물 1

HCID 470028801-Fluoro-2-[(trifluoromethyl)sulfanyl]benzene

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

실험 절차

Methyl viologen hydrochloride (1.17 g) in N,N-dimethylformamide (80 mL) at 25° C. was saturated with trifluoromethyl iodide, treated with 2-fluorobenzenethiol (9.7 mL) and triethylamine (20 mL), stirred for 24 hours, diluted with water (240 mL) and extracted with diethyl ether. The extract was washed with 1M aqueous NaOH, saturated ammonium chloride and brine and concentrated.

후처리

  1. customat 25° C.
  2. extractionextracted with diethyl ether
  3. washThe extract was washed with 1M aqueous NaOH, saturated ammonium chloride and brine
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ec467a4372804a8b94ec7fe1ca4179e8
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303025B2

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