Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 6-(4-Chlorophenyl)benzo[d][1,3]dioxole-5-carbaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 4-Chlorophenylboronic acid | HCID 74299 | — |
| 반응물 | 1,3-Benzodioxole-5-carboxaldehyde, 6-bromo- | HCID 95062 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Toluene | HCID 1140 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 6-(4-Chlorophenyl)benzo[d][1,3]dioxole-5-carbaldehyde | HCID 86642873 | — |
반응 단계
To a solution of 6-bromobenzo[d][1,3]dioxole-5-carbaldehyde (4.6 g), 4-chlorophenylboronic acid (3.78 g) and tetrakis(triphenylphosphine)palladium(0) (0.232 g) in toluene (80 mL) and methanol (30 mL) was added 2N aqueous Na2CO3 (30 mL). The mixture was stirred at reflux overnight. The mixture was diluted with ether (400 mL) and washed with water, brine and dried over Na2SO4. After filtration and concentration of the solvent, the residue was loaded on a column and eluted with 3% ethyl acetate in hexane to give the product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09303025B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-7249493d16b04d209be8c49e3d2a5f49 |
| 출처 메모 | uspto-grants-2016_04 |