Methanol → 6-Methoxy-1H-indol-5-ol

HRID 624380노트

반응식

HRID 624380 반응식
C([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][C:17]=1[O:18][CH3:19])[NH:14][CH:13]=[CH:12]2)C1C=CC=CC=1.CO.[H][H]>[OH-].[OH-].[Pd+2].C(OCC)(=O)C>[CH3:19][O:18][C:17]1[CH:16]=[C:15]2[C:11]([CH:12]=[CH:13][NH:14]2)=[CH:10][C:9]=1[OH:8]

참가 물질

6

반응물 3

HCID 887MethanolHCID 2608005-Benzyloxy-6-methoxyindoleHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 1649576-Methoxy-1H-indol-5-ol

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 8857Ethyl Acetate용매

실험 절차

5-(benzyloxy)-6-methoxy-1H-indole (3.00 g) was added to methanol (100 mL) and ethyl acetate (100 mL) in a pressure bottle. Palladium hydroxide on carbon (0.832 g) was added and the solution was shaken under 30 psi of hydrogen at room temperature for 40 minutes. The mixture was filtered through a nylon membrane, the solvent removed under vacuum, the residue taken up in ethyl acetate, the solution was filtered over a pad of silica gel, and the solvent was removed from the filtrate under vacuum.

후처리

  1. filtrationThe mixture was filtered through a nylon membrane
  2. customthe solvent removed under vacuum
  3. filtrationthe solution was filtered over a pad of silica gel
  4. customthe solvent was removed from the filtrate under vacuum

출처 및 근거

ORD 기록
ord-bf64eb067f644eb1ac2abfe43f46c627
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303025B2

반응 노트

불러오는 중…