Morpholine → 4-Morpholinobut-2-YN-1-OL

HRID 624407노트

반응식

HRID 624407 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[CH2:8][C:9]#[C:10][CH2:11][OH:12]>C1(C)C=CC=CC=1>[O:4]1[CH2:5][CH2:6][N:1]([CH2:8][C:9]#[C:10][CH2:11][OH:12])[CH2:2][CH2:3]1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 2027752-Butyn-1-ol, 4-chloro-

생성물 1

HCID 31128494-Morpholinobut-2-YN-1-OL

시약·촉매·용매 1

HCID 1140Toluene용매2회

반응 조건

온도
85 °C

실험 절차

To a solution of morpholine (4.36 g) in toluene (15 mL) was added 4-chlorobut-2-yn-1-ol (2.09 g) in toluene (5 mL). The solution was stirred at 85° C. for 3 hours. After cooling, the solid was filtered off. The filtrate was subjected to vacuum distillation to give the title compound.

후처리

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered off
  3. distillationThe filtrate was subjected to vacuum distillation

출처 및 근거

ORD 기록
ord-7da11824c80a41db8743d80325d60364
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303025B2

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