(2-Amino-4-chlorophenyl)methanol → 2-Amino-4-chlorobenzaldehyde

HRID 624526

반응식

HRID 624526 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH2:9][OH:10]>C(Cl)Cl.[O-2].[Mn+4].[O-2]>[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[CH:9]=[O:10]

참가 물질

4

반응물 1

HCID 4134900(2-Amino-4-chlorophenyl)methanol

생성물 1

HCID 112521382-Amino-4-chlorobenzaldehyde

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

In a 2 L 3-neck round bottom flask, the stirred solution of (2-amino-4-chlorophenyl)methanol 2 (32 g, 203.82 mmol) in DCM (765 mL), manganese (IV) oxide (150 g, 1.724 mol) was added at rt. The resulting reaction mixture was stirred at rt under argon atmosphere for 40 h. On completion of reaction the reaction mixture was filtered through CELITE™ pad and solid residue was washed thoroughly with DCM (1000 mL). The combined filtrate was concentrated under reduced pressure to give 2-amino-4-chlorobenzaldehyde as orange solid.

후처리

  1. customThe resulting reaction mixture
  2. customOn completion of reaction the reaction mixture
  3. filtrationwas filtered through CELITE™ pad and solid residue
  4. washwas washed thoroughly with DCM (1000 mL)
  5. concentrationThe combined filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-5996c7a069f843cfb8f7ee178a944e43
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303028B2

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