Potassium Hydroxide → HCID 118436743, 화합물

HRID 624657노트

반응식

HRID 624657 반응식
[F:1][C:2]([F:15])([F:14])[C:3]([NH:6][CH:7]=[C:8]([CH2:11][C:12]#[N:13])[C:9]#[N:10])([CH3:5])[CH3:4].[OH-].[K+]>CCO.O>[NH2:13][C:12]1[N:6]([C:3]([CH3:5])([CH3:4])[C:2]([F:14])([F:15])[F:1])[CH:7]=[C:8]([C:9]#[N:10])[CH:11]=1

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 900230042-(((1,1,1-Trifluoro-2-methylpropan-2-yl)amino)methylene)-succinonitrile

생성물 1

HCID 118436743HCID 118436743, 화합물

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

A solution of 2-(((1,1,1-trifluoro-2-methylpropan-2-yl)amino)methylene)-succinonitrile (187.2 mg, 0.862 mmol) in EtOH (539 μl) was added to a solution of KOH (87 mg, 1.551 mmol) in water (539 μl) at RT. After being stirred at RT for 4 h, the reaction mixture was concentrated under reduced pressure. The residual brown solid was taken up in water and sonicated. The resulting precipitate was collected by filtration, dissolved in EtOAc, washed with brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford the title compound as a brown solid, which was used without further purification.

후처리

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. customsonicated
  3. filtrationThe resulting precipitate was collected by filtration
  4. dissolutiondissolved in EtOAc
  5. washwashed with brine
  6. dry with materialdried over anhydrous Na2SO4
  7. filtrationfiltered
  8. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-eff3dbb058754ee5bdfe7dc1b20e21b0
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303045B2

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