Cesium carbonate → methyl 1-(thiazol-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate

HRID 624668노트

반응식

HRID 624668 반응식
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([C:10]([O:12][CH3:13])=[O:11])=[CH:2]1.Br[C:15]1[S:16][CH:17]=[CH:18][N:19]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN1C(=O)CCC1>[S:16]1[CH:17]=[CH:18][N:19]=[C:15]1[N:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([C:10]([O:12][CH3:13])=[O:11])=[CH:2]1

참가 물질

5

반응물 3

HCID 10796Cesium carbonateHCID 764302-BromothiazoleHCID 21110084methyl 1H-pyrrolo[2,3-b]pyridine-3-carboxylate

생성물 1

HCID 90030953methyl 1-(thiazol-2-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxylate

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

반응 조건

온도
130 °C

실험 절차

A mixture of methyl 1H-pyrrolo[2,3-b]pyridine-3-carboxylate (200 mg, 1.135 mmol), 2-bromothiazole (205 μl, 2.271 mmol) and cesium carbonate (1110 mg, 3.41 mmol) in NMP (1135 μl) was heated at 130° C. for 2 h. The mixture was then purified by HPLC to afford the title compound as a brownish-white solid.

후처리

  1. customThe mixture was then purified by HPLC

출처 및 근거

ORD 기록
ord-9cb94a1a285841d7a6191a7984af8102
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303045B2

반응 노트

불러오는 중…