Acetonitrile → 7-(Benzylthio)-5-chloropyrazolo[1,5-a]pyrimidine

HRID 624729노트

반응식

HRID 624729 반응식
[Cl:1][C:2]1[CH:7]=[C:6](Cl)[N:5]2[N:9]=[CH:10][CH:11]=[C:4]2[N:3]=1.[CH2:12]([SH:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(N(CC)CC)C.C(#N)C>O>[CH2:12]([S:19][C:6]1[N:5]2[N:9]=[CH:10][CH:11]=[C:4]2[N:3]=[C:2]([Cl:1])[CH:7]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

6

반응물 4

HCID 6342AcetonitrileHCID 7509Benzyl mercaptanHCID 8471TriethylamineHCID 110741545,7-Dichloropyrazolo[1,5-a]pyrimidine

생성물 1

HCID 583137227-(Benzylthio)-5-chloropyrazolo[1,5-a]pyrimidine수율 96%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To the reaction flask, 5,7-dichloropyrazolo[1,5-a]pyrimidine (4.1 g, 22 mmol) was added along with benzyl mercaptan (2.8 mL, 22 mmol), triethylamine (3.1 mL, 22 mmol), and acetonitrile (71 mL). The reaction was stirred at room temperature for 3 hours then diluted with water, filtered and washed with water. The product, 7-(benzylthio)-5-chloropyrazolo[1,5-a]pyrimidine, was collected as a solid in 96% yield after drying under vacuum overnight. LCMS (M+1=276)

후처리

  1. filtrationfiltered
  2. washwashed with water
  3. customThe product, 7-(benzylthio)-5-chloropyrazolo[1,5-a]pyrimidine, was collected as a solid in 96% yield
  4. customafter drying under vacuum overnight

출처 및 근거

ORD 기록
ord-e454c213931c4285bb85b567161dc124
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303033B2

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