Methyl 2-cyano-3,3-bis(methylsulfanyl)prop-2-enoate → HCID 178503357, 화합물

HRID 624816

반응식

HRID 624816 반응식
C[O:2][C:3](=O)[C:4]([C:10]#[N:11])=[C:5](SC)[S:6][CH3:7].[NH2:13][C:14]1[CH:18]=[CH:17][NH:16][N:15]=1>C(O)C>[OH:2][C:3]1[N:15]2[N:16]=[CH:17][CH:18]=[C:14]2[N:13]=[C:5]([S:6][CH3:7])[C:4]=1[C:10]#[N:11]

참가 물질

4

반응물 2

HCID 319957Methyl 2-cyano-3,3-bis(methylsulfanyl)prop-2-enoateHCID 178418806HCID 178418806, 화합물

생성물 1

HCID 178503357HCID 178503357, 화합물수율 67%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Under nitrogen gas atmosphere, 2-cyano-3,3-bismethylthio-2-propenoic methyl ester (6 g, 29.5 mmol) was added to ethanol (40 mL) along with 3-aminopyrazole (2.6 g, 31 mmol) and the mixture was refluxed for 2.5 hours. The reaction was then cooled to room temperature and precipitate was collected by filtration under vacuum. The solid was washed with ethanol and dried under vacuum to give 7-hydroxy-5-(methylthio)pyrazolo[1,5-a]pyrimidine-6-carbonitrile in 67% yield (4.1 g). This material was used for the next step without further purification. LCMS (M+1=207)

후처리

  1. temperaturethe mixture was refluxed for 2.5 hours
  2. filtrationprecipitate was collected by filtration under vacuum
  3. washThe solid was washed with ethanol
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-42f1683331804e74b76cc2792bba2865
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09303033B2

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