Cesium carbonate → 5-(4-Methoxy-3-(2-oxo-2-((2-oxotetrahydrofuran-3-yl)oxy)ethyl)phenyl)-dibenzothiophenium iodide

5-(3-(carboxymethyl)-4-methoxyphenyl)-dibenzothiophenium iodide (50 g, 105 mmol), 3-bromodihydrofuran-2(3H)-one (17.3 g, 105 mmol), and cesium carbonate (68.3 g, 210 mmol) are dissolved in DMF (400 mL) and stirred at 25° C. for 4 h. The reaction mixture is quenched with water (1 L), extracted with DCM (2×400 mL), the combined organic layers washed with water (4×500 mL), concentrated to a viscous oil and precipitated from MTBE (2 L) to afford the title compound as a white solid.

1. customThe reaction mixture is quenched with water (1 L)
2. extractionextracted with DCM (2×400 mL)
3. washthe combined organic layers washed with water (4×500 mL)
4. concentrationconcentrated to a viscous oil
5. customprecipitated from MTBE (2 L)

ORD 기록

ord-059c6fb29353494f8c832326b2bae1e0

출처 데이터셋

uspto-grants-2016_04

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US09304394B2