Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → HCID 66588098, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 3-(Trifluoromethyl)benzylic alcohol | HCID 67681 | — |
| 반응물 | 4-Chloro-6-(2-nitro-5-(piperidin-1-yl)phenyl)pyrimidine | HCID 86705928 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 66588098 | HCID 66588098 | — |
반응 단계
To a solution of 99 mg of 3-(trifluoromethyl)benzyl alcohol in 2 mL of DMF was added 27 mg of a 50% dispersion of sodium hydride in oil. After 15 min the solution was treated with 150 mg of intermediate 3.1b. After an additional 2 h the reaction mixture was partitioned between water and ethyl acetate. The organic extracts were washed with brine and dried (Na2SO4). The solvent was evaporated to give a yellow syrup that was used directly in the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09301951B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-4969a3e7c00549bbbf2591705a6162b3 |
| 출처 메모 | uspto-grants-2016_04 |