Acetyl chloride → D-Serine methyl ester hydrochloride
반응식
[NH2:1][C@@H:2]([C:5]([OH:7])=[O:6])[CH2:3][OH:4].[C:8]([Cl:11])(=O)C>CO>[ClH:11].[CH3:8][O:6][C:5](=[O:7])[C@@H:2]([CH2:3][OH:4])[NH2:1]참가 물질
4
실험 절차
D-serine (100 g, 0.9515 mole) was suspended in 600 ml methanol at room temperature. Acetyl chloride (224.0 g, 2.8545 mole) was added drop wise at −5° C. to 0° C. and stirred for 30 minutes. The reaction mixture was refluxed for 15 hours. Evaporation of the reaction mixture under reduced pressure followed by crystallization of the resulting residue from methanol and methyl tert-butyl ether, resulted in colorless solid of D-serine methyl ester hydrochloride (134.7 g, Yield: 91%, HPLC: 99.6%)
후처리
- temperatureThe reaction mixture was refluxed for 15 hours
- customEvaporation of the reaction mixture under reduced pressure
- customfollowed by crystallization of the resulting residue from methanol and methyl tert-butyl ether
출처 및 근거
- ORD 기록
- ord-3c91b85feed141eba2da4cf9e8233326
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09447024B1
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