Potassium Carbonate → Nonanoic acid, 9-hydroxy-, methyl ester
반응식
[CH3:1][O:2][C:3](=[O:14])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11](O)=[O:12].B.CSC.C([O-])([O-])=O.[K+].[K+]>C1COCC1>[CH3:1][O:2][C:3](=[O:14])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12]참가 물질
5
실험 절차
To a solution of nonanedioic acid monomethyl ester (4.80 g, 20 mmol) in THF (20 mL) at −20° C. was added a solution of borane-dimethylsulfide in THF (2.0 M, 10 mL) over 10 min. The resulting mixture was stirred for an additional 10 min, and then allowed to stir at room temperature overnight. Aqueous K2CO3 solution was added, and the product was extracted with ethyl ether (3×). The crude product was purified by flash column chromatography (hexane/EtOAc:2/1) to yield 9-hydroxy-nonanoic acid methyl ester 4-B (2.0 g, 55%).
후처리
- stirringto stir at room temperature overnight
- extractionthe product was extracted with ethyl ether (3×)
- customThe crude product was purified by flash column chromatography (hexane/EtOAc:2/1)
출처 및 근거
- ORD 기록
- ord-4ec8fd7e5739410b8e0301f960ca1723
- 출처 데이터셋
- uspto-grants-2016_04
- 특허 번호
- US09308272B2
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