Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Oxalate → HCID 178470312, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Oxalate | HCID 7268 | — |
| 반응물 | 2-Amino-4-fluorobenzamide | HCID 10241004 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | HCID 178470312 | HCID 178470312 | 22% |
반응 단계
A solution of 2-amino-4-fluorobenzamide (750 mg, 4.40 mmol), diethyl oxalate (20 mL), and AcOH (8 mL) was stirred at 140° C. for 16 h. The solid was collected by filtration and dried under reduced pressure to afford ethyl 7-fluoro-4-hydroxyquinazoline-2-carboxylate as a solid (235 mg, 22%). 1H NMR (300 MHz, DMSO-d6) δ 1.36 (t, J=7.08 Hz, 2H), 4.39 (q, J=7.08 Hz, 2H), 7.52 (m, 1H), 7.67 (m, 1H), 8.25 (m, 1H), 11.97 (br s, 1H), 12.77 (br s, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09308207B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-757e71033efc4958970f004e0b355c3d |
| 출처 메모 | uspto-grants-2016_04 |