Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 3-(benzyloxy)-5-bromo-1-methylpyridin-2(1H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-(benzyloxy)-5-bromopyridin-2(1H)-one | HCID 67406846 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-(benzyloxy)-5-bromo-1-methylpyridin-2(1H)-one | HCID 67417860 | 87.3% |
반응 단계
To a suspension of 2.51 g (8.96 mmol) 3-benzyloxy-5-bromo-1H-pyridin-2-one and 2.48 g (17.9 mmol) K2CO3 in 45 mL DMF was added 1.12 mL (17.9 mmol) iodomethane at room temperature. After stirring overnight, 150 mL water was added with vigorous stirring causing precipitation of the product which was collected by filtration and dried in vacuo affording 2.3 g (87%) 3-benzyloxy-5-bromo-1-methyl-1H-pyridin-2-one
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09309199B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-6dc501ab7a7043bba1f71557da576b5b |
| 출처 메모 | uspto-grants-2016_04 |