2-Acetoxybenzoyl chloride → 3-Acetamidobicyclo[1.1.1]pentan-1-yl 2-acetoxybenzoate

반응식

[OH:1][C:2]12[CH2:6][C:4]([NH:7][C:8](=[O:10])[CH3:9])([CH2:5]1)[CH2:3]2.[CH3:11][C:12]([O:14][C:15]1[C:20]([C:21](Cl)=[O:22])=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:13]>>[C:12]([O:14][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:20]=1[C:21]([O:1][C:2]12[CH2:6][C:4]([NH:7][C:8](=[O:10])[CH3:9])([CH2:5]1)[CH2:3]2)=[O:22])(=[O:13])[CH3:11]

참가 물질

반응물 2

HCID 796682-Acetoxybenzoyl chloride

HCID 86287953N-{3-hydroxybicyclo[1.1.1]pentan-1-yl}acetamide

생성물 1

HCID 862880273-Acetamidobicyclo[1.1.1]pentan-1-yl 2-acetoxybenzoate

실험 절차

The general procedure of Example 1 Step 3 is repeated starting with N-(3-hydroxybicyclo[1.1.1]pentan-1-yl)acetamide (1) and using O-acetylsalicyloyl chloride in place of the acetyl chloride to produce 3-acetamidobicyclo[1.1.1]pentan-1-yl 2-acetoxybenzoate (8).

출처 및 근거

ORD 기록: ord-273eca5867b241388ceba11b41776f3b
출처 데이터셋: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09447025B2

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