Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → (4-(2-Chloroethoxy)phenyl)(3-fluoro-4-hydroxyphenyl)methanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | (4-(2-Chloroethoxy)phenyl)(3-fluoro-4-methoxyphenyl)methanone | HCID 89656203 | — |
| 용매 | Hydrogen Bromide | HCID 260 | — |
| 생성물 | (4-(2-Chloroethoxy)phenyl)(3-fluoro-4-hydroxyphenyl)methanone | HCID 89656051 | 51% |
반응 단계
(4-(2-Chloroethoxy)phenyl)(3-fluoro-4-methoxyphenyl)methanone from the previous step in 20 mL 40% HBr was refluxed for 1 h., neutralized with solid Na2CO3 at 0° C., and extracted with EtOAc. The extract was washed with brine, dried, concentrated, and purified by column chromatography (eluent: petroleum ether/EtOAc=5/1 to 2/1) over silica gel to give the subtitle compound (731 mg, 51% yield for 3 steps) as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09309211B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-199cf749595d45de957133c948a279da |
| 출처 메모 | uspto-grants-2016_04 |