Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl orthoformate → 1,3-Benzoxazole-5-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl orthoformate | HCID 31214 | — |
| 반응물 | 3-Amino-4-hydroxybenzoic acid | HCID 65083 | — |
| 생성물 | 1,3-Benzoxazole-5-carboxylic acid | HCID 19006767 | 92% |
반응 단계
A mixture of 3-amino-4-hydroxybenzoic acid (8.0 g, 1.0 eq) and 60 mL CH(OEt)3 was heated to reflux for 3 h, and then cooled to rt. The remaining CH(OEt)3 was removed under reduced pressure to give the desired product (7.8 g, 92%). 1H NMR (400 MHz, DMSO-d6) δ 13.00 (brs, 1H), 8.85 (s, 1H), 8.30 (s, 1H), 8.03 (d, J=8.8 Hz, 1H), 7.85 (d, J=8.8 Hz, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09309211B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-3328fabf694640e6b5b931e5acca3048 |
| 출처 메모 | uspto-grants-2016_04 |