Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Phenylpropan-1-amine → HCID 178457662, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Phenylpropan-1-amine | HCID 18054 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 5-Benzimidazolecarboxylic acid | HCID 459456 | — |
| 반응물 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 178457662 | HCID 178457662 | — |
반응 단계
To a mixture of 5-benzimidazole-carboxylic acid in DMF was added DIPEA (1.3 equiv) and HATU (1.2 equiv). The mixture was stirred for 5 min, and then α-ethylbenzylamine (1.1 equiv) was added. The reaction mixture was stirred at rt. for 1 h. After the reaction was completed, the solvent was removed in vacuo to obtain the crude which was purified by flash chromatography to obtain the title compound. LC-MS 280 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09309227B2 |
| 출처 데이터셋 | uspto-grants-2016_04 |
| ORD ID | ord-361e8ee80b2f4d82aaeba12735cad980 |
| 출처 메모 | uspto-grants-2016_04 |