Water → (NE,S)-2-methyl-N-[1-(3-propan-2-ylphenyl)ethylidene]propane-2-sulfinamide

HRID 626395노트

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HRID 626395 반응식
[CH:1]([C:4]1[CH:5]=[C:6]([C:10](=O)[CH3:11])[CH:7]=[CH:8][CH:9]=1)([CH3:3])[CH3:2].[CH3:13][C:14]([S@@:17]([NH2:19])=[O:18])([CH3:16])[CH3:15].O>C1COCC1.CC(O[Ti](OC(C)C)(OC(C)C)OC(C)C)C>[CH:1]([C:4]1[CH:5]=[C:6](/[C:10](=[N:19]/[S@:17]([C:14]([CH3:16])([CH3:15])[CH3:13])=[O:18])/[CH3:11])[CH:7]=[CH:8][CH:9]=1)([CH3:3])[CH3:2]

참가 물질

6

반응물 3

HCID 962WaterHCID 30854921-[3-(Propan-2-yl)phenyl]ethan-1-oneHCID 11355477tert-Butylsulfinamide, (S)-(-)-

생성물 1

HCID 90373684(NE,S)-2-methyl-N-[1-(3-propan-2-ylphenyl)ethylidene]propane-2-sulfinamide

시약·촉매·용매 2

HCID 178460666HCID 178460666, 화합물촉매HCID 8028Tetrahydrofuran용매

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온도
90 °C

실험 절차

The mixture of 1-(3-isopropylphenyl)ethanone (5.8 g, 0.036 mol), (S)-2-methylpropane-2-sulfinamide (5.2 g, 0.043 mol) and Ti(OiPr)4 in THF was stirred at 90° C. for 16 hours. Then the mixture was poured to water and the solid was filtered, the filtrate was partitioned between EtOAc and water. The layers were separated and the organic layer was washed with water, brine, dried over Na2SO4, and concentrated. The residue was purified by column chromatography to give the titled compound.

후처리

  1. filtrationthe solid was filtered
  2. customthe filtrate was partitioned between EtOAc and water
  3. customThe layers were separated
  4. washthe organic layer was washed with water, brine
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated
  7. customThe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-4aec13a538694f578ad3705545c44689
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09309227B2

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