Potassium Carbonate → 4-[2-(2,5-Dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzaldehyde

HRID 62642

반응식

HRID 62642 반응식
Br[CH2:2][CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[O:10])=[CH:7][C:6]=1[O:13][CH3:14].[NH:15]1[C:19](=[O:20])[CH2:18][CH2:17][C:16]1=[O:21].C([O-])([O-])=O.[K+].[K+]>C(#N)C>[O:21]=[C:16]1[CH2:17][CH2:18][C:19](=[O:20])[N:15]1[CH2:2][CH2:3][O:4][C:5]1[CH:12]=[CH:11][C:8]([CH:9]=[O:10])=[CH:7][C:6]=1[O:13][CH3:14]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 11439SuccinimideHCID 160872944-(2-Bromoethoxy)-3-methoxybenzaldehyde

생성물 1

HCID 896106964-[2-(2,5-Dioxo-pyrrolidin-1-yl)-ethoxy]-3-methoxy-benzaldehyde

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

B method: 11.66 g (45 mmol) of 4-(2-bromo-ethoxy)-3-methoxy-benzaldehyde (6.2) and 4.46 g (45 mmol) pyrrolidine-2,5-dione (7.2) is heated with 8.28 g (60 mmol) K2CO3 in 200 ml of acetonitrile for 8 h. After same isolation procedure as in A method 4.1 is given with same purity.

출처 및 근거

ORD 기록
ord-cae274ee38054a5080d6f1068ecce66f
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447038B2

연결된 노트

불러오는 중…