Triethylamine → 1H-Indole-2-carboxamide

HRID 62644

반응식

HRID 62644 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]([OH:12])=O.C[N:14](C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(CC)CC>CN(C=O)C>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[C:2]1[C:10]([NH2:14])=[O:12]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 72899Indole-2-carboxylic acidHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

생성물 1

HCID 5948321H-Indole-2-carboxamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To indole-2-carboxylic acid (1e) (500 μL, 0.2 M in anhydrous DMF) was added HATU (250 μL, 0.4 M in anhydrous DMF) and Et3N (50 μL, 2.0 M in anhydrous DMF) and stirred for 5 minutes at room temperature. The desired amine (R6—NH2) was dissolved in 520 μL anhydrous DMF and added to the reaction mixture. The reaction mixture was stirred for two hours at 45° C. and the solvent was evaporated in vacuo and the residue was purified via preparative HPLC to obtain the desired product indole-2-carboxamide (I).

후처리

  1. additionadded to the reaction mixture
  2. stirringThe reaction mixture was stirred for two hours at 45° C.
  3. customthe solvent was evaporated in vacuo
  4. customthe residue was purified via preparative HPLC

출처 및 근거

ORD 기록
ord-e66f91d3cee4486fb48425e2aee0cf67
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447039B2

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