Methylamine → N4-[2-(2,6-Dichlorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-yl]-6,N2-dimethylpyrimidine-2,4-diamine

HRID 626671

반응식

HRID 626671 반응식
ClC1C=CC=C(Cl)[C:3]=1[N:9]1C=C2C(NC3C=C(NC)N=CN=3)=NC=CC2=N1.Cl[C:28]1[N:33]=[C:32]([NH:34][C:35]2[C:40]3=[CH:41][N:42]([C:44]4[C:49]([Cl:50])=[CH:48][CH:47]=[CH:46][C:45]=4[Cl:51])[N:43]=[C:39]3[CH:38]=[CH:37][N:36]=2)[CH:31]=[C:30]([CH3:52])[N:29]=1.CN>>[Cl:51][C:45]1[CH:46]=[CH:47][CH:48]=[C:49]([Cl:50])[C:44]=1[N:42]1[CH:41]=[C:40]2[C:35]([NH:34][C:32]3[CH:31]=[C:30]([CH3:52])[N:29]=[C:28]([NH:9][CH3:3])[N:33]=3)=[N:36][CH:37]=[CH:38][C:39]2=[N:43]1

참가 물질

4

반응물 3

HCID 6329MethylamineHCID 69671122N-[2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridine-4-yl]-N'-methylpyrimidine-4,6-diamineHCID 86697041(2-Chloro-6-methylpyrimidin-4-yl)-[2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-yl]amine

생성물 1

HCID 67700612N4-[2-(2,6-Dichlorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-yl]-6,N2-dimethylpyrimidine-2,4-diamine수율 33%

실험 절차

Following the procedure described for N-[2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridine-4-yl]-N′-methylpyrimidine-4,6-diamine, (2-chloro-6-methylpyrimidin-4-yl)-[2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-yl]amine and methylamine were reacted to afford the title compound as a yellow solid (24 mg, 33% yield). 1H NMR (400 MHz, DMSO-d6): δ 9.88 (s, 1H), 9.16 (s, 1H), 7.94 (d, J=6.4 Hz, 1H), 7.81-7.80 (m, 2H), 7.70 (dd, J=9.0, 7.3 Hz, 1H), 7.65 (s, 1H), 7.15 (dd, J=6.4, 1.0 Hz, 1H), 2.82 (d, J=4.8 Hz, 3H), 2.25 (s, 3H). LCMS (Method B): RT=2.90 min, m/z: 400 [M+H+].

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-778fa9713d1049e18bfdbe2b78235295
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09309240B2

연결된 노트

불러오는 중…