HCID 178510122, 화합물 → 3-Chloro-5-fluoro-2-(7-fluoropyrazolo[4,3-c]pyridin-2-yl)-benzonitrile

HRID 626782노트

반응식

HRID 626782 반응식
[N:1]([C:4]1[C:9]([F:10])=[CH:8][N:7]=[CH:6][C:5]=1/[CH:11]=[N:12]/[C:13]1[C:20]([Cl:21])=[CH:19][C:18]([F:22])=[CH:17][C:14]=1[C:15]#[N:16])=[N+]=[N-]>C1(C)C=CC=CC=1>[Cl:21][C:20]1[C:13]([N:12]2[CH:11]=[C:5]3[CH:6]=[N:7][CH:8]=[C:9]([F:10])[C:4]3=[N:1]2)=[C:14]([CH:17]=[C:18]([F:22])[CH:19]=1)[C:15]#[N:16]

참가 물질

3

반응물 1

HCID 178510122HCID 178510122, 화합물

생성물 1

HCID 696715683-Chloro-5-fluoro-2-(7-fluoropyrazolo[4,3-c]pyridin-2-yl)-benzonitrile수율 93%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of 2-{[1-(4-azido-5-fluoropyridin-3-yl)-meth-(E)-ylidene]-amino}-3-chloro-5-fluorobenzonitrile (1.67 g, 5.25 mmol) in anhydrous toluene (25 mL) was heated under reflux for 4.5 hours. The resultant mixture was allowed to cool to room temperature and concentrated under reduced pressure. The residue was purified by silica gel flash chromatography (0-5% methanol in DCM) to afford the title compound as a yellow solid (1.41 g, 93% yield). LCMS (Method C): RT=2.71 min, m/z: 291 [M+H+].

후처리

  1. temperatureunder reflux for 4.5 hours
  2. concentrationconcentrated under reduced pressure
  3. customThe residue was purified by silica gel flash chromatography (0-5% methanol in DCM)

출처 및 근거

ORD 기록
ord-514e778e05a64fccaa7634d7029e9b2d
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09309240B2

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