Diethylamine → tert-butyl N-[(3R)-3-[3-[4-(5-ethoxy-2-fluoro-phenyl)-6-methyl-pyrimidin-2-yl]prop-2-ynyl]-1-methyl-2-oxo-pyrrolidin-3-yl]carbamate

반응식

[CH3:1][N:2]1[CH2:6][CH2:5][C@:4]([NH:10][C:11](=[O:17])[O:12][C:13]([CH3:16])([CH3:15])[CH3:14])([CH2:7][C:8]#[CH:9])[C:3]1=[O:18].[CH2:19]([O:21][C:22]1[CH:23]=[CH:24][C:25]([F:36])=[C:26]([C:28]2[CH:33]=[C:32]([CH3:34])[N:31]=[C:30](I)[N:29]=2)[CH:27]=1)[CH3:20].N(CC)CC>C1COCC1.CCOC(C)=O.CCCC(C)C.[Cu](I)I>[CH2:19]([O:21][C:22]1[CH:23]=[CH:24][C:25]([F:36])=[C:26]([C:28]2[CH:33]=[C:32]([CH3:34])[N:31]=[C:30]([C:9]#[C:8][CH2:7][C@@:4]3([NH:10][C:11](=[O:17])[O:12][C:13]([CH3:15])([CH3:14])[CH3:16])[CH2:5][CH2:6][N:2]([CH3:1])[C:3]3=[O:18])[N:29]=2)[CH:27]=1)[CH3:20]