(2-Chloropyrimidin-5-yl)boronic acid → [2-(4-Methoxycarbonyl-4-methylpiperidin-1-yl)pyrimidin-5-yl]boronic acid

HRID 626932

반응식

HRID 626932 반응식
[CH3:1][O:2][C:3]([C:5]1([CH3:11])[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)=[O:4].Cl[C:13]1[N:18]=[CH:17][C:16]([B:19]([OH:21])[OH:20])=[CH:15][N:14]=1>>[CH3:1][O:2][C:3]([C:5]1([CH3:11])[CH2:6][CH2:7][N:8]([C:13]2[N:18]=[CH:17][C:16]([B:19]([OH:21])[OH:20])=[CH:15][N:14]=2)[CH2:9][CH2:10]1)=[O:4]

참가 물질

3

반응물 2

HCID 21747362(2-Chloropyrimidin-5-yl)boronic acidHCID 51072294Methyl 4-methylpiperidine-4-carboxylate

생성물 1

HCID 89923873[2-(4-Methoxycarbonyl-4-methylpiperidin-1-yl)pyrimidin-5-yl]boronic acid

실험 절차

Prepared from 4-methylpiperidine-4-carboxylic acid methyl ester and (2-chloropyrimidin-5-yl)boronic acid according to the method of Intermediate 45.

출처 및 근거

ORD 기록
ord-974c909284da46e2860657eee900111c
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09309243B2

연결된 노트

불러오는 중…