HCID 89852058, 화합물 → (3R,6S)-3-(allyloxyamino)-6-(methoxymethyl)-1,2,3,6-tetrahydro-pyridine-4-carboxamide

HRID 627147노트

반응식

HRID 627147 반응식
[CH2:1]([O:4][N:5]([C@@H:18]1[C:23]([C:24]([NH2:26])=[O:25])=[CH:22][C@@H:21]([CH2:27][O:28][CH3:29])[NH:20][CH2:19]1)S(C1C=CC=CC=1[N+]([O-])=O)(=O)=O)[CH:2]=[CH2:3].C(ON[C@@H]1C(C(N)=O)=C[C@@H](CO[Si](C(C)(C)C)(C)C)NC1)C=C.C(ON([C@@H]1C(C(N)=O)=C[C@@H](CO[Si](C(C)(C)C)(C)C)NC1)S(C1C=CC([N+]([O-])=O)=CC=1[N+]([O-])=O)(=O)=O)C=C>>[CH2:1]([O:4][NH:5][C@@H:18]1[C:23]([C:24]([NH2:26])=[O:25])=[CH:22][C@@H:21]([CH2:27][O:28][CH3:29])[NH:20][CH2:19]1)[CH:2]=[CH2:3]

참가 물질

4

반응물 3

HCID 89852058HCID 89852058, 화합물2회HCID 89852509(3R,6S)-3-(N-(allyloxy)-2,4-dinitrophenylsulfonamido)-6-((tert-butyldimethylsilyloxy)methyl)-1,2,3,6-tetrahydropyridine-4-carboxamideHCID 89852545(3R,6S)-3-(allyloxyamino)-6-((tert-butyldimethylsilyloxy)methyl)-1,2,3,6-tetrahydropyridine-4-carboxamide

생성물 1

HCID 89852143(3R,6S)-3-(allyloxyamino)-6-(methoxymethyl)-1,2,3,6-tetrahydro-pyridine-4-carboxamide

실험 절차

This intermediate was prepared from (3R,6S)-3-(N-(allyloxy)-2-nitrophenylsulfonamido)-6-(methoxymethyl)-1,2,3,6-tetrahydropyridine-4-carboxamide (Intermediate 113, 734 mg, 1.36 mmol) using the same procedure and isolation techniques to prepare Intermediate 107 from Intermediate 106. The title compound was an orange oil (173 mg, 53%).

출처 및 근거

ORD 기록
ord-6c1b09798cf74edfa03c45a290077c0a
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09309245B2

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