반응식
[Cl-].[Ce+3].[Cl-].[Cl-].[CH2:5]([Mg]Br)[CH3:6].[CH3:9][C:10]1([CH3:26])[N:14]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[C@@H:13]([C:22]([O:24]C)=O)[CH2:12][O:11]1.[CH2:27]1COC[CH2:28]1>>[OH:24][C:22]([C@H:13]1[CH2:12][O:11][C:10]([CH3:9])([CH3:26])[N:14]1[C:15]([O:17][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:16])([CH2:5][CH3:6])[CH2:27][CH3:28]참가 물질
반응 조건
- 온도
- -78 °C
실험 절차
A suspension of cerium (III) chloride (119 g, 482.07 mmol) in THF (350 mL) at room temperature was stirred vigorously for 2 hours. The suspension was cooled to −78° C. and ethylmagnesium bromide (482 mL, 482.07 mmol) was added dropwise. The mixture was stirred at −78° C. for 1.5 hours. (R)-3-tert-butyl 4-methyl 2,2-dimethyloxazolidine-3,4-dicarboxylate (Aldrich, 25 g, 96.41 mmol) in THF (100 mL) was then added dropwise at −78° C. The reaction was stirred at −78° C. for 30 minutes and then warmed to 0° C. for 15 minutes. The reaction was quenched with saturated NH4Cl, diluted further with water and extracted twice with ether. The organics were dried over magnesium sulfate, filtered and concentrated. Silica gel chromatography (0%-20% ethyl acetate/hexanes) afforded the title compound (26.4 g, 95%) as a colorless oil.
후처리
- stirringThe mixture was stirred at −78° C. for 1.5 hours
- stirringThe reaction was stirred at −78° C. for 30 minutes
- temperaturewarmed to 0° C. for 15 minutes
- customThe reaction was quenched with saturated NH4Cl
- additiondiluted further with water
- extractionextracted twice with ether
- dry with materialThe organics were dried over magnesium sulfate
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-8c7716b9b106400ca34f40fd57b9152c
- 출처 데이터셋
- uspto-grants-2016_04
- 특허 번호
- US09309245B2
연결된 노트
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