Thionyl Chloride → 2-Fluoropyridine-5-carbonyl chloride

반응식

[F:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([OH:10])=O)=[CH:4][CH:3]=1.S(Cl)([Cl:13])=O>>[F:1][C:2]1[N:7]=[CH:6][C:5]([C:8]([Cl:13])=[O:10])=[CH:4][CH:3]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 2428196-Fluoronicotinic Acid

생성물 1

HCID 146236022-Fluoropyridine-5-carbonyl chloride

반응 조건

온도: 80 °C

실험 절차

In a 100-mL round-bottom flask was placed a solution of 6-fluoropyridine-3-carboxylic acid (5.0 g, 35.4 mmol) in thionyl chloride (20 mL). The resulting solution was heated at 80° C. for 2 hours and concentrated under vacuum to give the title compound as a yellow oil.

후처리

customIn a 100-mL round-bottom flask was placed
concentrationconcentrated under vacuum

출처 및 근거

ORD 기록: ord-7ebacbd88c974eeaa7baa374f072bab9
출처 데이터셋: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09309222B2

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