2-Amino-5-bromobenzoic acid → HCID 178515323, 화합물

HRID 627502

반응식

HRID 627502 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([Br:11])=[CH:7][C:3]=1[C:4]([OH:6])=O.[F:12][C:13]([F:24])([F:23])[C:14](=O)[CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.CS(O)(=O)=O.O=P12OP3(OP(OP(O3)(O1)=O)(=O)O2)=O>O>[Br:11][C:8]1[CH:7]=[C:3]2[C:2](=[CH:10][CH:9]=1)[N:1]=[C:14]([C:13]([F:23])([F:24])[F:12])[C:15]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[C:4]2[OH:6]

참가 물질

5

반응물 3

HCID 798582-Amino-5-bromobenzoic acidHCID 2229581,1,1-Trifluoro-3-phenyl-2-propanoneHCID 86584057Phosphorus Pentoxide-Methanesulfonic Acid

생성물 1

HCID 178515323HCID 178515323, 화합물

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

A mixture of 2-amino-5-bromobenzoic acid (3.01 g, 13.9 mmol), 1,1,1-trifluoro-3-phenylpropan-2-one (3.11 g, 16.5 mmol), and Eaton's reagent (9.3 mL) in a sealed tube was heated at 100° C. for 4 hours. The reaction mixture was then allowed to cool to room temperature, water was added slowly, and the mixture was stirred vigorously for about 15 min. The precipitated solid was filtered, washed with water, and dried to give the title compound.

후처리

  1. temperatureto cool to room temperature
  2. filtrationThe precipitated solid was filtered
  3. washwashed with water
  4. customdried

출처 및 근거

ORD 기록
ord-bc9ca85abd7b4788aa124e5e9ac7b94a
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09309222B2

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