Tetrahydrofuran → 2-Iodo-3-(2-thiophen-3-ylethoxy)-pyridine

참여 물질

역할	이름	HCID	투입량
반응물	Tetrahydrofuran	HCID 8028	—
반응물	Triphenylphosphine	HCID 11776	—
반응물	Diisopropyl diazene-1,2-dicarboxylate	HCID 75555	—
반응물	Thiophene-3-ethanol	HCID 83731	—
반응물	2-Iodopyridin-3-ol	HCID 97179	—
생성물	2-Iodo-3-(2-thiophen-3-ylethoxy)-pyridine	HCID 57900311	90%

반응 단계

To a solution containing 2-iodo-3-hydroxypyridine 12 (1.85 g, 8.37 mmol), 2-(3-thienyl)ethanol (1.20 mL, 10.9 mmol), and triphenylphosphine (2.85 g, 10.9 mmol) in tetrahydrofuran (46.2 mL, 5.70 mmol) was added diisopropyl azodicarboxylate (2.14 mL, 10.9 mmol) dropwise. The reaction mixture was stirred at room temperature for 18 h. The reaction mixture was concentrated and purified by flash chromatography EtOAc/Hex (0-100%) eluted at 30% to give 13 (yield 90%). MS: (ESI+) 332.2

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09309265B2
출처 데이터셋	uspto-grants-2016_04
ORD ID	ord-ac00b591bdbc4c4d901eefaf6f43c6eb
출처 메모	uspto-grants-2016_04