Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → 7-Hydroxyisoflavone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | Ethylorthoformate | HCID 53630039 | — |
| 반응물 | 2,4-Dihydroxy-phenyl-benzyl-ketone | HCID 54014987 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 7-Hydroxyisoflavone | HCID 5376891 | 90.5% |
반응 단계
A mixture of 100 kg (438.5 mole) of 2,4-dihydroxy-phenyl-benzyl-ketone, 38 kg of dimethyl-formamide, 5.2 kg of morpholine and 75 kg (506 mole) of ethyl-orthoformate is stirred at 80°-90° C., while within one hour crystallization is initiated. 360 kg of chloroform are added to the suspension after 7 hours at 60° C. After cooling the crystalline substance is centrifuged, covered with chloroform, filtered and dried. 94.5 kg of 7-hydroxy-isoflavone are obtained, 7-ethoxy-isoflavone content: 0.1% by weight, yield: 90.5%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05247102 |
| 출처 데이터셋 | uspto-grants-1993_09 |
| ORD ID | ord-e89dd36c6e3b43d29e69f02bfcdffabb |
| 출처 메모 | uspto-grants-1993_09 |