Trifluoroacetic acid → HCID 178511296, 화합물

HRID 628357노트

반응식

HRID 628357 반응식
[C:1]([C@H:3]1[CH2:6][C@H:5]([NH:7]C(=O)OC(C)(C)C)[CH2:4]1)#[N:2].[C:15]([OH:21])([C:17]([F:20])([F:19])[F:18])=[O:16]>C(Cl)Cl>[F:18][C:17]([F:20])([F:19])[C:15]([OH:21])=[O:16].[NH2:7][C@H:5]1[CH2:6][C@H:3]([C:1]#[N:2])[CH2:4]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 178454087HCID 178454087, 화합물

생성물 1

HCID 178511296HCID 178511296, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

tert-Butyl (trans-3-cyanocyclobutyl)carbamate (0.061 g, 0.31 mmol) was stirred with TFA (2 mL) in DCM (4 mL) for 1 hour. The solvents were removed in vacuo and the residue was reconstituted in DCM and subjected to rotary evaporation an additional 2 times to rid of excess TFA in the product, which was used without further purification in Step 5.

후처리

  1. customThe solvents were removed in vacuo
  2. customsubjected to rotary evaporation an additional 2 times
  3. customwas used without further purification in Step 5

출처 및 근거

ORD 기록
ord-f07d0eb518f742c2895ae1c18e1f6d79
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09309246B2

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