(E)-3-(4-benzyloxy-3,5-difluoro-phenyl)-acrylic acid ethyl ester → Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate

참여 물질

반응 단계

(E)-3-(4-Benzyloxy-3,5-difluoro-phenyl)-acrylic acid ethyl ester (1.2 g, 3.77 mmol) obtained in Step C was dissolved in EtOH (20 mL), and 10% Pd/C (120 mg) was added to the solution. The mixture was stirred at room temperature under hydrogen atmosphere for 12 hours. The reactant was filtered by using celite and concentrated under reduced pressure to obtain the title compound (0.85 g, 98%).

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