Water → (6-Sec-butylsulfanyl-pyridin-2-yl)-methanol

HRID 62840노트

반응식

HRID 62840 반응식
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([S:12][CH:13]([CH2:15][CH3:16])[CH3:14])[N:7]=1)=O)C.[Li+].[BH4-].O>C1COCC1>[CH:13]([S:12][C:8]1[N:7]=[C:6]([CH2:4][OH:3])[CH:11]=[CH:10][CH:9]=1)([CH2:15][CH3:16])[CH3:14]

참가 물질

5

반응물 3

HCID 962WaterHCID 4148881Lithium borohydrideHCID 901182566-Sec-butylsulfanyl-pyridine-2-carboxylic acid ethyl ester

생성물 1

HCID 90118289(6-Sec-butylsulfanyl-pyridin-2-yl)-methanol수율 90%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
40 °C

실험 절차

6-sec-Butylsulfanyl-pyridine-2-carboxylic acid ethyl ester (0.17 g, 0.71 mmol) obtained in Step A was dissolved in anhydrous THF (3 mL). 2.0 M LiBH4 solution (0.5 mL, 1.0 mmol) was added thereto, and the mixture was stirred at 40° C. for 1 hour. After the termination of the reaction, the reactant was cooled to room temperature. The reactant was added with water and then extracted with EtOAc. The organic layer was separated, dried with MgSO4, and concentrated under reduced pressure to obtain the title compound (0.126 g, 90%).

후처리

  1. customAfter the termination of the reaction
  2. temperaturethe reactant was cooled to room temperature
  3. extractionextracted with EtOAc
  4. customThe organic layer was separated
  5. dry with materialdried with MgSO4
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-0c405c0f80fc440a97b9ac682ac47e2a
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447044B2

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