Benzyl Bromide → 1-(Benzyloxy)-4-bromo-2-fluorobenzene

HRID 62841

반응식

HRID 62841 반응식
C([O-])([O-])=O.[K+].[K+].[CH2:7](Br)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[Br:15][C:16]1[CH:21]=[CH:20][C:19]([OH:22])=[C:18]([F:23])[CH:17]=1>CN(C=O)C>[CH2:7]([O:22][C:19]1[CH:20]=[CH:21][C:16]([Br:15])=[CH:17][C:18]=1[F:23])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 27249814-Bromo-2-fluorophenol

생성물 1

HCID 187574911-(Benzyloxy)-4-bromo-2-fluorobenzene수율 101.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

DMF (12 mL), K2CO3(1.19 g, 8.55 mmol) and benzyl bromide (0.75 mL, 6.27 mmol) was added to 4-bromo-2-fluorophenol (1.1 g, 5.7 mmol), and the mixture was stirred at room temperature for 2 hours. After the termination of the reaction, the reactant was concentrated and the residue was diluted with 20 mL water. The mixture was extracted with EtOAc. The organic layer was separated and dried with MgSO4 to obtain the title compound (1.62 g, 100%).

후처리

  1. customAfter the termination of the reaction
  2. concentrationthe reactant was concentrated
  3. additionthe residue was diluted with 20 mL water
  4. extractionThe mixture was extracted with EtOAc
  5. customThe organic layer was separated
  6. dry with materialdried with MgSO4

출처 및 근거

ORD 기록
ord-02bc1bb165664703bc47e99c5b59c704
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447044B2

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