(E)-3-(4-benzyloxy-3-fluoro-phenyl)-acrylic acid methyl ester → HCID 22558806, 화합물

HRID 62843노트

반응식

HRID 62843 반응식
[CH3:1][O:2][C:3](=[O:21])/[CH:4]=[CH:5]/[C:6]1[CH:11]=[CH:10][C:9]([O:12]CC2C=CC=CC=2)=[C:8]([F:20])[CH:7]=1>CCOC(C)=O.CO.[Pd]>[CH3:1][O:2][C:3](=[O:21])[CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]([F:20])[CH:7]=1

참가 물질

5

반응물 1

HCID 90118296(E)-3-(4-benzyloxy-3-fluoro-phenyl)-acrylic acid methyl ester

생성물 1

HCID 22558806HCID 22558806, 화합물수율 105.1%

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

(E)-3-(4-Benzyloxy-3-fluoro-phenyl)-acrylic acid methyl ester (0.37 g, 1.2 mmol) obtained in Step B was dissolved in EtOAc (4 mL) and MeOH (2 mL). The solution was added with 10% Pd/C (0.03 g), and the mixture was stirred under hydrogen atmosphere for 18 hours. The reactant was filtered by using celite, and the filtrate was washed with EtOAc to obtain the title compound (0.25 g, 98%).

후처리

  1. filtrationThe reactant was filtered
  2. washthe filtrate was washed with EtOAc

출처 및 근거

ORD 기록
ord-55e6e12f805e47d785edb998192d92c3
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447044B2

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