Sodium Bicarbonate → 1-(2-Methoxymethyl-3-bromophenyl)-4-methyl-1,4-dihydrotetrazol-5-one

HRID 628495노트

반응식

HRID 628495 반응식
Br[CH2:2][C:3]1[C:8]([Br:9])=[CH:7][CH:6]=[CH:5][C:4]=1[N:10]1[C:14](=[O:15])[N:13]([CH3:16])[N:12]=[N:11]1.C[O-].[Na+].[C:20](=O)(O)[O-:21].[Na+]>O1CCCC1>[CH3:20][O:21][CH2:2][C:3]1[C:8]([Br:9])=[CH:7][CH:6]=[CH:5][C:4]=1[N:10]1[C:14](=[O:15])[N:13]([CH3:16])[N:12]=[N:11]1

참가 물질

5

반응물 3

HCID 516892Sodium BicarbonateHCID 10942334Sodium MethoxideHCID 898756621-(2-Bromomethyl-3-bromophenyl)-4-methyl-1,4-dihydrotetrazol-5-one

생성물 1

HCID 898762251-(2-Methoxymethyl-3-bromophenyl)-4-methyl-1,4-dihydrotetrazol-5-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 1-(2-bromomethyl-3-bromophenyl)-4-methyl-1,4-dihydrotetrazole-5-one 45.0 g, sodium methoxide 37.4 g and tetrahydrofuran 600 ml was stirred at room temperature for three hours. To the reaction mixture was added aqueous saturated sodium bicarbonate solution and the resulting mixture was extracted with ethyl acetate. The organic layer was washed with aqueous saturated sodium bicarbonate solution and was dried over anhydrous magnesium sulfate. The resulting mixture was concentrated under reduced pressure to give 1-(2-methoxymethyl-3-bromophenyl)-4-methyl-1,4-dihydrotetrazole-5-one 36.2 g.

후처리

  1. extractionthe resulting mixture was extracted with ethyl acetate
  2. washThe organic layer was washed with aqueous saturated sodium bicarbonate solution
  3. dry with materialwas dried over anhydrous magnesium sulfate
  4. concentrationThe resulting mixture was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-64e1bc762b704889896dddabedffa327
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09314023B2

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