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Potassium Carbonate → 1-{3-Bromo-2-[2-methyl-4-(3,4,5-trimethyl-pyrazol-1-yl)-phenoxymethyl]-phenyl}-4-methyl-1,4-dihydrotetrazole-5-one

HRID 628518
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인쇄 미리보기

반응식

HRID 628518 반응식
Br[CH2:2][C:3]1[C:8]([Br:9])=[CH:7][CH:6]=[CH:5][C:4]=1[N:10]1[C:14](=[O:15])[N:13]([CH3:16])[N:12]=[N:11]1.[CH3:17][C:18]1[CH:23]=[C:22]([N:24]2[C:28]([CH3:29])=[C:27]([CH3:30])[C:26]([CH3:31])=[N:25]2)[CH:21]=[CH:20][C:19]=1[OH:32].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Br:9][C:8]1[C:3]([CH2:2][O:32][C:19]2[CH:20]=[CH:21][C:22]([N:24]3[C:28]([CH3:29])=[C:27]([CH3:30])[C:26]([CH3:31])=[N:25]3)=[CH:23][C:18]=2[CH3:17])=[C:4]([N:10]2[C:14](=[O:15])[N:13]([CH3:16])[N:12]=[N:11]2)[CH:5]=[CH:6][CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 898756621-(2-Bromomethyl-3-bromophenyl)-4-methyl-1,4-dihydrotetrazol-5-oneHCID 118236550Methyl-4-(3,4,5-trimethyl-pyrazol-1-yl)-phenol

생성물 1

HCID 1182365091-{3-Bromo-2-[2-methyl-4-(3,4,5-trimethyl-pyrazol-1-yl)-phenoxymethyl]-phenyl}-4-methyl-1,4-dihydrotetrazole-5-one수율 86.7%

시약·촉매·용매 1

HCID 6342
Acetonitrile
용매

실험 절차

A mixture of 1-(2-bromomethyl-3-bromophenyl)-4-methyl-1,4-dihydrotetrazole-5-one (described in Reference Preparation example 11) 3.1 g, 2-methyl-4-(3,4,5-trimethyl-pyrazol-1-yl)-phenol (described in Reference Preparation example 20) 1.6 g, potassium carbonate 1.3 g and acetonitrile 70 ml was stirred with heating under reflux for six hours, and the reaction mixture was then filtered and was concentrated under reduced pressure. The resulting residue was subjected to a silica gel column chromatography to give 1-{ 3-bromo-2-[2-methyl-4-(3,4,5-trimethyl-pyrazol-1-yl)-phenoxymethyl]-phenyl}-4-methyl-1,4-dihydrotetrazole-5-one 3.1 g.

후처리

  1. temperaturewith heating
  2. temperatureunder reflux for six hours
  3. filtrationthe reaction mixture was then filtered
  4. concentrationwas concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-28959d94acf241d6b9a41cf38fe91f95
출처 데이터셋
uspto-grants-2016_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US09314023B2

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