Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Propanethiol → 6-Isopropylsulfanyl-pyridine-2-carboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Propanethiol | HCID 6364 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | Methyl 6-bromopyridine-2-carboxylate | HCID 16217886 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 6-Isopropylsulfanyl-pyridine-2-carboxylic acid methyl ester | HCID 90118297 | 89.2% |
반응 단계
6-Bromo-pyridine-2-carboxylic acid methyl ester (0.15 g, 0.69 mmol) was added with DMF (2.3 mL), Cs2CO3(0.45 g, 1.38 mmol) and 2-propanethiol (0.064 mL, 0.69 mmol) in turn, and the mixture was stirred at room temperature for 18 hours. After the termination of the reaction, the reactant was filtered and concentrated under reduced pressure to obtain the title compound (0.13 g, 88%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09447044B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-792a4140021c4e56b730b7d41a6c301c |
| 출처 메모 | uspto-grants-2016_09 |