Methyl 3-chloropyrazine-2-carboxylate → HCID 178499101, 화합물

HRID 62863노트

반응식

HRID 62863 반응식
[CH3:1][O:2][C:3]([C:5]1[C:10](Cl)=[N:9][CH:8]=[CH:7][N:6]=1)=[O:4].O.[SH-:13].[Na+]>CO>[CH3:1][O:2][C:3]([C:5]1[C:10]([SH:13])=[N:9][CH:8]=[CH:7][N:6]=1)=[O:4]

참가 물질

4

반응물 2

HCID 1519497Methyl 3-chloropyrazine-2-carboxylateHCID 16211346Sodium hydrosulfide hydrate

생성물 1

HCID 178499101HCID 178499101, 화합물수율 89.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

After 3-chloro-pyrazine-2-carboxylic acid methyl ester (0.4 g, 2.3 mmol) was dissolved in MeOH (46 mL), sodium hydrosulfide monohydrate (0.65 g, 6.9 mmol) was added thereto, and the mixture was stirred at room temperature for 9 hours. After the termination of the reaction, the reactant was concentrated under reduced pressure, and 1N HCl aqueous solution was used to adjust the pH of the reactant to 3. The reactant was extracted with EtOAc, and the organic layer was separated to obtain the title compound (0.35 g, 89%).

후처리

  1. customAfter the termination of the reaction
  2. concentrationthe reactant was concentrated under reduced pressure, and 1N HCl aqueous solution
  3. extractionThe reactant was extracted with EtOAc
  4. customthe organic layer was separated

출처 및 근거

ORD 기록
ord-f1f4215d401d4b258248d4ffd75b3f69
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09447044B2

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