Tryptamine hydrochloride → Kumujian A

HRID 628666

반응식

HRID 628666 반응식
Cl.[NH2:2][CH2:3][CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1.[CH2:14]([O:16][C:17](=[O:20])[CH:18]=O)[CH3:15]>C(O)C.C1(C)C=CC=CC=1>[CH2:14]([O:16][C:17]([C:18]1[C:6]2[NH:7][C:8]3[C:13]([C:5]=2[CH:4]=[CH:3][N:2]=1)=[CH:12][CH:11]=[CH:10][CH:9]=3)=[O:20])[CH3:15]

참가 물질

5

반응물 2

HCID 67652Tryptamine hydrochlorideHCID 70211Ethyl oxoacetate

생성물 1

HCID 11701473Kumujian A

시약·촉매·용매 2

HCID 702Ethanol용매HCID 1140Toluene용매

실험 절차

To a suspension of tryptamine hydrochloride (2.00 g, 10.17 mmol) in ethanol (25 mL) was added a solution of glyoxylic acid ethyl ester (3.12 g, 15.26 mmol) in toluene (50% v/v) at 0° C. After the reaction mixture was stirred overnight at ambient temperature, the solvent was removed under reduced pressure. The resulting residue was treated with saturated aqueous sodium bicarbonate. The product was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate and concentrated under reduced pressure. The crude product was used in the next step without further purification.

후처리

  1. customthe solvent was removed under reduced pressure
  2. additionThe resulting residue was treated with saturated aqueous sodium bicarbonate
  3. extractionThe product was extracted with ethyl acetate
  4. washThe combined organic layers were washed with brine
  5. dry with materialdried over sodium sulfate
  6. concentrationconcentrated under reduced pressure
  7. customThe crude product was used in the next step without further purification

출처 및 근거

ORD 기록
ord-3b814fa746c84ca6bacc617ccb47992d
출처 데이터셋
uspto-grants-2016_04
특허 번호
US09314468B2

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