Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → (2-Isopropylsulfanyl-pyrimidin-4-yl)-methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | 2-Isopropylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester | HCID 90118331 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (2-Isopropylsulfanyl-pyrimidin-4-yl)-methanol | HCID 90118246 | 77.7% |
반응 단계
After 2-isopropylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester (0.1 g, 0.44 mmol) obtained in Step B was dissolved in MeOH (4 mL), NaBH4(0.033 g, 0.9 mmol) was added to the solution, and the mixture was stirred at room temperature for 2 hours. After the termination of the reaction, the reactant was added with water, and then extracted with EtOAc. The separated organic layer was dried with MgSO4 and separated by column chromatography to obtain the title compound (0.063 g, 77%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09447044B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-b31d92927b9e4c29b9f49751a7272251 |
| 출처 메모 | uspto-grants-2016_09 |