참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | Bromocyclobutane | HCID 78110 | — |
| 반응물 | HCID 178468955 | HCID 178468955 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 6-Cyclobutylsulfanyl-pyridine-2-carboxylic acid ethyl ester | HCID 90118276 | 93% |
반응 단계
After 6-mercapto-pyridine-2-carboxylic acid ethyl ester (0.40 g, 2.18 mmol) was dissolved in CH3CN (9 mL), Cs2CO3(2.667 g, 6.54 mmol) and bromo cyclobutane (0.385 mL, 3.27 mmol) were added thereto, and the mixture was stirred at 50° C. for 18 hours. After the termination of the reaction, the reactant was filtered, concentrated under reduced pressure, and purified by column chromatography (eluent, EtOAc/Hex=1/5) to obtain the title compound (0.481 g, 92%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09447044B2 |
|---|
| 출처 데이터셋 | uspto-grants-2016_09 |
|---|
| ORD ID | ord-4a4cf27f8d9946788a2fdf48713ee108 |
|---|
| 출처 메모 | uspto-grants-2016_09 |
|---|
