Cyclopentanethiol → 2-Cyclopentylsulfanyl-6-methoxy-nicotinic acid methyl ester

반응식

[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[N:6][C:5]=1Cl.[CH:14]1([SH:19])[CH2:18][CH2:17][CH2:16][CH2:15]1>>[CH3:1][O:2][C:3](=[O:13])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[N:6][C:5]=1[S:19][CH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1

참가 물질

반응물 2

HCID 15510Cyclopentanethiol

HCID 10584232Methyl 2-chloro-6-methoxynicotinate

생성물 1

HCID 901181632-Cyclopentylsulfanyl-6-methoxy-nicotinic acid methyl ester수율 77%

실험 절차

2-Chloro-6-methoxy-nicotinic acid methyl ester (54 mg, 0.26 mmol) and cyclopen-tanethiol were reacted in the same manner as in Step A of Preparation Example 16 to obtain the title compound (55 mg, 77%).

출처 및 근거

ORD 기록: ord-e70926e9fcc74d7ca1763b3f81742b6f
출처 데이터셋: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09447044B2

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