Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzyl Bromide → 4-(Benzyloxy)-2-chlorobenzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 2-Chloro-4-hydroxybenzaldehyde | HCID 185363 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 4-(Benzyloxy)-2-chlorobenzaldehyde | HCID 14034077 | 59% |
반응 단계
2-Chloro-4-hydroxy-benzaldehyde obtained in Step A was dissolved in CH3CN (20 mL). After Cs2CO3(8.7 g, 0.027 mol) was added thereto, benzyl bromide (1.5 mL, 0.013 mol) was added thereto, and the mixture was stirred at room temperature for 2 hours. After the termination of the reaction, the reactant was filtered by using celite, concentrated under reduced pressure, and purified by column chromatography (eluent, EtOAc/Hex=1/5) to obtain the title compound (1.89 g, 59%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09447044B2 |
| 출처 데이터셋 | uspto-grants-2016_09 |
| ORD ID | ord-558ef29b1e9c468b94748d66fc4d701c |
| 출처 메모 | uspto-grants-2016_09 |